Myelodysplastic Syndrome Complicated with Leukemia Cutis

We herein presented a 50-year-old female of myelodysplastic syndrome sub-typing refractory anemia with excess blasts. She had received conservative and immunosuppressive therapies, but not controlled well. One year later, multiple asymptomatic, erythematous papules, plaques and nodules developed over trunk and four limbs. The histopathological and immunohistochemical studies showed atypical mononuclear cells infiltrate positively stained with CD45 and myeloperoxidase in the whole dermis, indicating the diagnosis of leukemia cutis. Then, the bone marrow biopsy was suggested and acute myeloid leukemia was diagnosed. In spite of vigorous chemotherapy, the patient died of intracerebral hemorrhage in one week. (Dermatol Sinica 22 : 248-253, 2004)